Niclosamide ni bioavailable yo mu kanwa ya chlorine salicylanilide, hamwe na anthelmintic kandi ishobora gukora antineoplastique.Iyo ubuyobozi bwo mu kanwa, niclosamide itera kwangirika kwa reseptor ya androgene (AR) V7 (AR-V7) ikoresheje inzira ya proteasome-yunganirwa.Ibi bigabanya imvugo ya AR ihinduka, ikabuza ibikorwa byo kwanduza AR-V7-yunganirwa, kandi bikagabanya kwinjiza AR-V7 muri poroteyine yihariye ya poroteyine (PSA).Niclosamide irinda kandi AR-V7-yunganirwa na STAT3 fosifora no gukora.Ibi birabuza ibimenyetso bya AR / STAT3 byunganirwa kandi bikabuza kwerekana imiterere ya gen.Hamwe na hamwe, ibi birashobora kubuza gukura kwa AR-V7-kanseri ikabije ya kanseri.Impinduka ya AR-V7, igizwe no guterana kwa AR exons 1/2/3 / CE3, igengwa nubwoko butandukanye bwa kanseri, kandi ifitanye isano no gutera kanseri ndetse no kurwanya imiti igamije AR.

Ibigize:

Buri bolus cotnains 1250 mg niclosamide

Icyerekana:

Ku matungo yanduye paramphistomes, cestodiyasi, nka moniezia yinka nintama, avitellina centripunctata, nibindi.

Imikoreshereze n'imikoreshereze:

Mubisanzwe buri 1 kg uburemere bwumubiri.

Inka: 40-60mg

Intama: 60-70mg

Igihe cyo gukuramo:

Intama: iminsi 28.

Inka: iminsi 28.

Ingano yububiko: ibinini 5 kuri blisteri, ibisebe 10 kumasanduku